Spravato® (esketamine) is an FDA-approved nasal spray used in the treatment of adults with treatment-resistant depression (TRD) and major depressive disorder (MDD) with acute suicidal ideation or behavior. Developed as a breakthrough therapy, Spravato represents a significant advancement in psychiatric care, offering new hope to patients who have not found sufficient relief through traditional antidepressant medications. At Balanced Mental Health of Arizona, we are proud to offer Spravato treatment as part of our comprehensive approach to mental wellness.
What Is Spravato?
Spravato is a nasal spray formulation of esketamine, a derivative of ketamine that works differently from conventional antidepressants. While most antidepressants target serotonin, dopamine, or norepinephrine systems, esketamine acts on the NMDA (N-methyl-D-aspartate) receptor — a glutamate receptor in the brain involved in mood regulation and neural connectivity. This unique mechanism of action allows Spravato to produce antidepressant effects more rapidly than traditional medications, sometimes within hours to days rather than the weeks typically required for standard antidepressants to take effect.
Because Spravato has the potential for misuse and requires monitoring for sedation and dissociation following administration, it is only available through a restricted distribution program called the Spravato REMS (Risk Evaluation and Mitigation Strategy). This means treatment must be administered in a certified healthcare setting under direct medical supervision — patients self-administer the nasal spray under the observation of a qualified provider, then remain at the facility for monitoring for at least two hours after each dose.
Who May Benefit from Spravato?
Spravato is specifically indicated for adults who have tried at least two different antidepressant medications without achieving adequate relief — a condition known as treatment-resistant depression — or for those experiencing major depressive disorder alongside active suicidal thoughts or behaviors. It is used in combination with a standard oral antidepressant, not as a standalone treatment. Candidates for Spravato are carefully evaluated by our provider to ensure the treatment is appropriate given the individual's full medical and psychiatric history, current medications, and overall health status.
Is Spravato Right for You?
If you have been living with depression that has not responded adequately to previous treatments, Spravato may be a valuable option to discuss with our team. Our provider will conduct a thorough evaluation to determine whether Spravato is a medically appropriate and safe choice for your individual circumstances. We are committed to providing personalized, compassionate care and will work closely with you to develop a treatment plan designed to support lasting mental wellness.
Spravato Treatment Near Me in Phoenix, AZ
To learn more about Spravato or to find out whether you may be a candidate for this treatment, contact Balanced Mental Health of Arizona at (623) 349-1711 or request an appointment online. Our dedicated team is here to guide you toward the relief and recovery you deserve.